Professor David Cosgrove

Professor David Cosgrove

Date of Birth: May 18th, 1938

Degrees

1961
BA (Physiology) 1990 MA Oxford
1963 BM BCh London and Oxford
1967 MRCP 1990 FRCP London
1975 MSc in Nuclear Medicine London
1988 FRCR by invitation London


Summary of Posts held

Current
Senior Research Investigator, Imperial College School of Medicine and Consultant in Radiology, Hammersmith Hospital, London
1997-2004 Professor of Clinical Ultrasound, Imperial College School of Medicine and Honorary Consultant in Radiology, Hammersmith Hospital, London
1977-1993 Consultant in Nuclear Medicine and Ultrasound, Royal Marsden Hospital, London

My four main themes of academic activity are:

  1. Advancing the clinical role of "radiological" (i.e. non-obstetric) ultrasound;
  2. Furthering understanding of the basic mechanisms of the ultrasound image-forming process and of Doppler;
  3. Applications of microbubble echo-enhancing (“contrast”) agents for ultrasound.
  4. Application of Elastography to clinical diagnosis.

The first is exemplified by several first reports of clinically significant ultrasound findings, e.g. the features of biliary tree dilatation, pneumobilia, hæmangiomas, abdominal tumours of various types, thyroid diseases, fatty changes in the liver, the use of Doppler in breast diagnosis and transit time analysis of microbubbles in tumours.

The second has resulted in a series of reports on the mechanisms of ultrasound appearances (e.g. artefacts, such as transdiaphragmatic echoes) and on exploring novel means to extract hitherto unavailable information from the ultrasound signals. Generally known as “tissue characterisation”, this work has been carried out in close collaboration with the department of Physics at the Institute of Cancer Research, particularly with Dr. Jeff Bamber and his colleagues. These studies have provided insight into the extreme complexity of the interactions between ultrasound and tissue and may yield practical applications (e.g. speckle reduction, induced motion analysis or elastography). Doppler studies have focused on the clinical evaluation and introduction of new techniques such as colour and power Doppler.

The recently introduced echo enhancing (“contrast”) agents have become the major focus of study with the establishment of a research team to investigate this unique opportunity both from fundamental and clinical points of view. Fundamental studies include non-linear imaging and quantification of the change in echogenicity with microbubble concentration leading to functional indices and imaging. Clinical studies include phase III trials with a range of microbubble agents (especially in the liver and in tumours) and functional studies (especially in diffuse and focal liver diseases and in tumours).

Elastography, a recently introduced method of imaging and quantifying tissue stiffness, is undergoing clinical trials and is in early clinical use. I have been instrumental in several early and more recent stages in this process.

Recent Publicatiions

Peer-reviewed Journals:
Taylor, PC, Steuer, A, Gruber, J, McClinton, C, Cosgrove, DO, Blomley, MJ, Marsters, PA, Wagner, CL, Maini, RN. Ultrasonographic and radiographic results from a two-year controlled trial of immediate or one-year-delayed addition of infliximab to ongoing methotrexate therapy in patients with erosive early rheumatoid arthritis. Arthritis Rheum (2006) 54:47-53.
Cosgrove, DO. A revolution in liver ultrasound. Eur J Gastroenterol Hepatol (2007) 19:1-2.
Ellis, SM, Naoumova, RP, Neuwirth, CK, Eckersley, R, Cosgrove, DO, Thompson, GR, Sidhu, PS. Measurement of the reflectivity of the intima-medial layer of the common carotid artery improves the discriminatory value of intima-medial thickness measurement as a predictor of risk of atherosclerotic disease. Ultrasound Med Biol (2007) 33:1029-1038.
Greenbaum, L, Burns, P, Copel, J, Cosgrove, D,et al. American Institute of Ultrasound in Medicine recommendations for contrast-enhanced liver ultrasound imaging clinical trials. J Ultrasound Med (2007) 26:705-716.
Claudon, M, Cosgrove, Det al Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008. Ultraschall Med (2008) 29:28-44.
Wink, M, Frauscher, F, Cosgrove, D, et al. Contrast enhanced ultrasound and prostate cancer; A multicentre European research coordination project. European Urology (2008) e publication 20 June, PMID: 18584944
Cosgrove DO, Chan KK. Renal transplants: what ultrasound can and cannot do. Ultrasound Quarterly, (2008) 24(2): 77-87.
Lloyd, C, Hart, JL, Niewiarowski, S, Lim, A, Harvey, C, Cosgrove, D. Ultrasound in breast imaging. Br J Hosp Med (Lond). 2008; 69:M6-9.
Cosgrove DO, Harvey C. Clinical Uses of Microbubbles in Diagnosis and Treatment. Medical and Biological Engineering and Computing. In press 2009.
Cosgrove D, Lassau N. Évaluation de l’angiogénèse tumorale à l’aide de l’échographie de contraste. J Radiol (2009) 90:156-64.
Shiyan L, Pintong H, Zongmin W, Fuguang H, Zhiqiang Z, Yan Y and Cosgrove D, The relationship between enhanced intensity and microvessel density of gastric carcinoma using double contrast-enhanced ultrasonography. Ultrasound Med Biol, 2009. 35(7): p. 1086-91.
Cosgrove D, Sonoelastography. Hospital Imaging and Radiology Europe, 2009. 4(2): p. 47-48.
Rattansingh A, Adamson B and Cosgrove D, Bidirectional flow within the intratesticular arteries caused by microvenous thrombosis secondary to testicular torsion. J Ultrasound Med, 2009. 28(6): p. 817-21.
Grier S, Patel N, Yu-Ting K, Cosgrove DO, Goldin RC, Thomas HC, Taylor-Robinson SD and Lim A. Perihepatic lymph nodes as markers of disease response in patients with hepatitis C-related liver disease: a prospective clinical evaluation. European Journal of Gastroenterology & Hepatology 2010, 22:257–263
Sorelli PG, Cosgrove DO, Svensson WE, Zaman N, Satchithananda K, Barrett NK, Lim AK Can contrast-enhanced sonography distinguish benign from malignant breast masses?
J Clin Ultrasound 38(4):177-181 May 2010
Cosgrove DO Contrast-Enhanced Ultrasound of Liver Lesions.
Ultrasound Med Biol 27 Aug 2010 (letter)

Textbooks:
Dawson P, Cosgrove DO and Grainger RG. (Eds + numerous chapters) Textbook of Contrast Media. Oxford, ISIS Medical Press, 1999. (ISBN 1 899066 31 4)
(2nd edition in preparation 2010)

Chapters:
Liang H-D, Blomley MJK and Cosgrove DO. Therapeutic applications of microbubble-based agents, Ch 30, in Quaia E (ed) Contrast Media in Ultrasonography: Basic Principles and Clinical Applications. Springer-Verlag Berlin (2004) ISBN-10: 3540407405
Cosgrove DO . “Ultrasound and Contrast Ultrasound” Ch 1 in Focal Liver Lesions: Detection, Characterization, Ablation. Lencioni R, D. Cioni D, and Bartolozzi C Eds. Springer, Heidelberg (2005) ISBN: 3-540-64464-4
Cosgrove DO. Breast Ultrasound, Ch 39 in Fleischer A, Jeanty P, Manning FA, Romero R, Lee W and Toy EC, eds Sonography in Obstetrics and Gynaecology. McGraw Hill, New York (6th ed 2004) ISBN 0838580424
7th edition in progress for 2010.
Cosgrove DO “Ultrasound in radiology – state-of-the-art” in Ultrasound in clinical diagnosis: From pioneering developments in Lund to global application in medicine, Eklöf B, Lindström K and Persson S Eds Oxford University Press in press for 2011